Forkhead box protein G1 (FOXG1)

About Forkhead box protein G1

Forkhead box protein G1 (FOXG1) is a protein from Homo sapiens identified by UniProt accession P55316, 489 residues long. MolForge cross-references it against 0 known binders and 242 disease associations.

Target properties

Protein name	Forkhead box protein G1
UniProt accession	P55316
Gene	FOXG1
Organism	Homo sapiens
Length	489 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (242)

Diseases linked to this target (Open Targets).

Rett syndrome · score 0.72
FOXG1 disorder · score 0.67
genetic disorder · score 0.54
cortical surface area measurement · score 0.45
Neurodevelopmental disorder · score 0.43
cortical thickness · score 0.40
mathematical ability · score 0.40
undetermined early-onset epileptic encephalopathy · score 0.37
urate measurement · score 0.36
bone density · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55316-F1	alphafold	PREDICTED	57.47	—

Amino-acid sequence (489 residues)

MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP PAPQPPPPPQ QQQPPPPPPP APQPPQTRGA PAADDDKGPQ QLLLPPPPPP PPAAALDGAK ADGLGGKGEP GGGPGELAPV GPDEKEKGAG AGGEEKKGAG EGGKDGEGGK EGEKKNGKYE KPPFSYNALI MMAIRQSPEK RLTLNGIYEF IMKNFPYYRE NKQGWQNSIR HNLSLNKCFV KVPRHYDDPG KGNYWMLDPS SDDVFIGGTT GKLRRRSTTS RAKLAFKRGA RLTSTGLTFM DRAGSLYWPM SPFLSLHHPR ASSTLSYNGT TSAYPSHPMP YSSVLTQNSL GNNHSFSTAN GLSVDRLVNG EIPYATHHLT AAALAASVPC GLSVPCSGTY SLNPCSVNLL AGQTSYFFPH VPHPSMTSQS STSMSARAAS SSTSPQAPST LPCESLRPSL PSFTTGLSGG LSDYFTHQNQ GSSSNPLIH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards