Hepatocyte nuclear factor 3-alpha (FOXA1)

About Hepatocyte nuclear factor 3-alpha

Hepatocyte nuclear factor 3-alpha (FOXA1) is a protein from Homo sapiens identified by UniProt accession P55317, 472 residues long. MolForge cross-references it against 0 known binders and 419 disease associations.

Target properties

Protein name	Hepatocyte nuclear factor 3-alpha
UniProt accession	P55317
Gene	FOXA1
Organism	Homo sapiens
Length	472 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (419)

Diseases linked to this target (Open Targets).

prostate adenocarcinoma · score 0.67
breast adenocarcinoma · score 0.51
prostate carcinoma · score 0.41
eosinophil count · score 0.38
breast ductal adenocarcinoma · score 0.37
Breast Carcinoma by Gene Expression Profile · score 0.37
lobular breast carcinoma · score 0.37
Mixed Lobular and Ductal Breast Carcinoma · score 0.37
Prostate Small Cell Carcinoma · score 0.37
breast carcinoma · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55317-F1	alphafold	PREDICTED	55.65	—

Amino-acid sequence (472 residues)

MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ AASMNGLGPY AAAMNPCMSP MAYAPSNLGR SRAGGGGDAK TFKRSYPHAK PPYSYISLIT MAIQQAPSKM LTLSEIYQWI MDLFPYYRQN QQRWQNSIRH SLSFNDCFVK VARSPDKPGK GSYWTLHPDS GNMFENGCYL RRQKRFKCEK QPGAGGGGGS GSGGSGAKGG PESRKDPSGA SNPSADSPLH RGVHGKTGQL EGAPAPGPAA SPQTLDHSGA TATGGASELK TPASSTAPPI SSGPGALASV PASHPAHGLA PHESQLHLKG DPHYSFNHPF SINNLMSSSE QQHKLDFKAY EQALQYSPYG STLPASLPLG SASVTTRSPI EPSALEPAYY QGVYSRPVLN TS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards