About Hepatocyte nuclear factor 3-gamma
Hepatocyte nuclear factor 3-gamma (FOXA3) is a protein
from Homo sapiens identified by UniProt accession
P55318, 350 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Hepatocyte nuclear factor 3-gamma |
|---|
| UniProt accession | P55318 |
|---|
| Gene | FOXA3 |
|---|
| Organism | Homo sapiens |
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| Length | 350 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (111)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.52
- neurodegenerative disease · score 0.44
- BMI-adjusted waist-hip ratio · score 0.21
- head and neck squamous cell carcinoma · score 0.18
- Beta blocking agent use measurement · score 0.14
- eosinophil count · score 0.13
- waist-hip ratio · score 0.12
- asthma · score 0.11
- cutaneous melanoma · score 0.11
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55318-F1 | alphafold | PREDICTED | 62.17 | — |
Amino-acid sequence (350 residues)
MLGSVKMEAH DLAEWSYYPE AGEVYSPVTP VPTMAPLNSY MTLNPLSSPY PPGGLPASPL PSGPLAPPAP AAPLGPTFPG LGVSGGSSSS GYGAPGPGLV HGKEMPKGYR RPLAHAKPPY SYISLITMAI QQAPGKMLTL SEIYQWIMDL FPYYRENQQR WQNSIRHSLS FNDCFVKVAR SPDKPGKGSY WALHPSSGNM FENGCYLRRQ KRFKLEEKVK KGGSGAATTT RNGTGSAAST TTPAATVTSP PQPPPPAPEP EAQGGEDVGA LDCGSPASST PYFTGLELPG ELKLDAPYNF NHPFSINNLM SEQTPAPPKL DVGFGGYGAE GGEPGVYYQG LYSRSLLNAS
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