About Lens fiber membrane intrinsic protein
Lens fiber membrane intrinsic protein (LIM2) is a protein
from Homo sapiens identified by UniProt accession
P55344, 173 residues long.
MolForge cross-references it against 0 known binders and
213 disease associations.
Target properties
| Protein name | Lens fiber membrane intrinsic protein |
|---|
| UniProt accession | P55344 |
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| Gene | LIM2 |
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| Organism | Homo sapiens |
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| Length | 173 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (213)
Diseases linked to this target (Open Targets).
- early-onset non-syndromic cataract · score 0.53
- cataract · score 0.37
- neurodegenerative disease · score 0.37
- total early-onset cataract · score 0.37
- neutrophil count · score 0.27
- neutrophil percentage of leukocytes · score 0.24
- sum of basophil and neutrophil counts · score 0.21
- genetic disorder · score 0.19
- glaucoma · score 0.19
- lymphocyte percentage of leukocytes · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55344-F1 | alphafold | PREDICTED | 90.32 | — |
Amino-acid sequence (173 residues)
MYSFMGGGLF CAWVGTILLV VAMATDHWMQ YRLSGSFAHQ GLWRYCLGNK CYLQTDSIAY WNATRAFMIL SALCAISGII MGIMAFAHQP TFSRISRPFS AGIMFFSSTL FVVLALAIYT GVTVSFLGRR FGDWRFSWSY ILGWVAVLMT FFAGIFYMCA YRVHECRRLS TPR
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