Protein arginine N-methyltransferase 2 (PRMT2)

About Protein arginine N-methyltransferase 2

Protein arginine N-methyltransferase 2 (PRMT2) is a protein from Homo sapiens identified by UniProt accession P55345, 433 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Protein arginine N-methyltransferase 2
UniProt accession	P55345
Gene	PRMT2
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.08
renal cell carcinoma · score 0.08
acute myeloid leukemia · score 0.07
monocyte percentage of leukocytes · score 0.07
glioblastoma multiforme · score 0.07
mean corpuscular volume · score 0.06
atherosclerosis · score 0.06
neoplasm · score 0.06
t-tau:beta-amyloid 1-42 ratio measurement · score 0.06
diabetes mellitus · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55345-F1	alphafold	PREDICTED	91.86	—

Amino-acid sequence (433 residues)

MATSGDCPRS ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL RQTTADWWWG ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP RTTKYHSVIL QNKESLTDKV ILDVGCGTGI ISLFCAHYAR PRAVYAVEAS EMAQHTGQLV LQNGFADIIT VYQQKVEDVV LPEKVDVLVS EWMGTCLLFE FMIESILYAR DAWLKEDGVI WPTMAALHLV PCSADKDYRS KVLFWDNAYE FNLSALKSLA VKEFFSKPKY NHILKPEDCL SEPCTILQLD MRTVQISDLE TLRGELRFDI RKAGTLHGFT AWFSVHFQSL QEGQPPQVLS TGPFHPTTHW KQTLFMMDDP VPVHTGDVVT GSVVLQRNPV WRRHMSVALS WAVTSRQDPT SQKVGEKVFP IWR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards