Homeobox protein PKNOX1 (PKNOX1)

About Homeobox protein PKNOX1

Homeobox protein PKNOX1 (PKNOX1) is a protein from Homo sapiens identified by UniProt accession P55347, 436 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

Target properties

Protein name	Homeobox protein PKNOX1
UniProt accession	P55347
Gene	PKNOX1
Organism	Homo sapiens
Length	436 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
endometrial cancer · score 0.23
breast adenocarcinoma · score 0.22
head and neck squamous cell carcinoma · score 0.15
neutrophil count · score 0.13
myeloid white cell count · score 0.13
gastric adenocarcinoma · score 0.07
melanoma · score 0.07
metabolite measurement · score 0.07
reticular dysgenesis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55347-F1	alphafold	PREDICTED	60.61	—

Amino-acid sequence (436 residues)

MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards