Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)

About Heterogeneous nuclear ribonucleoprotein H2

Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) is a protein from Homo sapiens identified by UniProt accession P55795, 449 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.

Target properties

Protein name	Heterogeneous nuclear ribonucleoprotein H2
UniProt accession	P55795
Gene	HNRNPH2
Organism	Homo sapiens
Length	449 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (113)

Diseases linked to this target (Open Targets).

intellectual disability, X-linked, syndromic, Bain type · score 0.73
genetic disorder · score 0.43
complex neurodevelopmental disorder · score 0.37
Neurodevelopmental delay · score 0.35
Neurodevelopmental disorder · score 0.34
Abnormal facial shape · score 0.34
stereotypic movement disorder · score 0.34
Fabry disease · score 0.16
Angiokeratoma corporis diffusum · score 0.15
glioblastoma multiforme · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55795-F1	alphafold	PREDICTED	61.17	—

Amino-acid sequence (449 residues)

MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE GRPSGEAFVE LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards