About Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1) is a protein
from Homo sapiens identified by UniProt accession
P55809, 520 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial |
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| UniProt accession | P55809 |
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| Gene | OXCT1 |
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| Organism | Homo sapiens |
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| Length | 520 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- succinyl-CoA:3-ketoacid CoA transferase deficiency · score 0.83
- neurodegenerative disease · score 0.35
- Ketonuria · score 0.28
- heel bone mineral density · score 0.25
- genetic disorder · score 0.19
- non-small cell lung carcinoma · score 0.10
- glioblastoma multiforme · score 0.08
- osteosarcoma · score 0.08
- gonorrhea · score 0.06
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55809-F1 | alphafold | PREDICTED | 91.91 | — |
Amino-acid sequence (520 residues)
MAALKLLSSG LRLCASARGS GATWYKGCVC SFSTSAHRHT KFYTDPVEAV KDIPDGATVL VGGFGLCGIP ENLIDALLKT GVKGLTAVSN NAGVDNFGLG LLLRSKQIKR MVSSYVGENA EFERQYLSGE LEVELTPQGT LAERIRAGGA GVPAFYTPTG YGTLVQEGGS PIKYNKDGSV AIASKPREVR EFNGQHFILE EAITGDFALV KAWKADRAGN VIFRKSARNF NLPMCKAAET TVVEVEEIVD IGAFAPEDIH IPQIYVHRLI KGEKYEKRIE RLSIRKEGDG EAKSAKPGDD VRERIIKRAA LEFEDGMYAN LGIGIPLLAS NFISPNITVH LQSENGVLGL GPYPRQHEAD ADLINAGKET VTILPGASFF SSDESFAMIR GGHVDLTMLG AMQVSKYGDL ANWMIPGKMV KGMGGAMDLV SSAKTKVVVT MEHSAKGNAH KIMEKCTLPL TGKQCVNRII TEKAVFDVDK KKGLTLIELW EGLTVDDVQK STGCDFAVSP KLMPMQQIAN
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