SH3 domain-binding glutamic acid-rich protein (SH3BGR)

About SH3 domain-binding glutamic acid-rich protein

SH3 domain-binding glutamic acid-rich protein (SH3BGR) is a protein from Homo sapiens identified by UniProt accession P55822, 239 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	SH3 domain-binding glutamic acid-rich protein
UniProt accession	P55822
Gene	SH3BGR
Organism	Homo sapiens
Length	239 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.22
pulse pressure measurement · score 0.12
heel bone mineral density · score 0.03
inflammatory bowel disease · score 0.03
body height · score 0.02
total cholesterol measurement · score 0.02
smoking status measurement · score 0.02
smoking behavior · score 0.02
metabolite measurement · score 0.02
bone quantitative ultrasound measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P55822-F1	alphafold	PREDICTED	66.38	—

Amino-acid sequence (239 residues)

MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD RGVLGGVLFP TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL DIAGDEDNRR WMRENVPGEK KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE ENIIYSFLGL APPPDSKGSE KAEEGGETEA QKEGSEDVGN LPEAQEKNEE EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards