About Dicarboxylate carrier SLC25A8
Dicarboxylate carrier SLC25A8 (UCP2) is a protein
from Homo sapiens identified by UniProt accession
P55851, 309 residues long.
MolForge cross-references it against 0 known binders and
403 disease associations.
Target properties
| Protein name | Dicarboxylate carrier SLC25A8 |
|---|
| UniProt accession | P55851 |
|---|
| Gene | UCP2 |
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| Organism | Homo sapiens |
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| Length | 309 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (403)
Diseases linked to this target (Open Targets).
- hyperinsulinism due to UCP2 deficiency · score 0.37
- mean platelet volume · score 0.27
- obesity due to melanocortin 4 receptor deficiency · score 0.23
- hyperinsulinism · score 0.19
- type 2 diabetes mellitus · score 0.11
- neoplasm · score 0.11
- non-small cell lung carcinoma · score 0.10
- Stroke · score 0.10
- Sepsis · score 0.08
- atherosclerosis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55851-F1 | alphafold | PREDICTED | 62.52 | — |
Amino-acid sequence (309 residues)
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP VRATASAQYR GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHASIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYQSTV NAYKTIAREE GFRGLWKGTS PNVARNAIVN CAELVTYDLI KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA ACTSREAPF
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