About Eukaryotic translation initiation factor 3 subunit B
Eukaryotic translation initiation factor 3 subunit B (EIF3B) is a protein
from Homo sapiens identified by UniProt accession
P55884, 814 residues long.
MolForge cross-references it against 0 known binders and
74 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 3 subunit B |
|---|
| UniProt accession | P55884 |
|---|
| Gene | EIF3B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 814 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (74)
Diseases linked to this target (Open Targets).
- myeloid white cell count · score 0.18
- monocyte percentage of leukocytes · score 0.15
- cystatin C measurement · score 0.11
- neoplasm · score 0.11
- leukocyte count · score 0.09
- gonorrhea · score 0.09
- platelet count · score 0.09
- esophageal squamous cell carcinoma · score 0.09
- melanoma · score 0.09
- head and neck squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P55884-F1 | alphafold | PREDICTED | 73.24 | — |
Amino-acid sequence (814 residues)
MQDAENVAVP EAAEERAEPG QQQPAAEPPP AEGLLRPAGP GAPEAAGTEA SSEEVGIAEA GPESEVRTEP AAEAEAASGP SESPSPPAAE ELPGSHAEPP VPAQGEAPGE QARDERSDSR AQAVSEDAGG NEGRAAEAEP RALENGDADE PSFSDPEDFV DDVSEEELLG DVLKDRPQEA DGIDSVIVVD NVPQVGPDRL EKLKNVIHKI FSKFGKITND FYPEEDGKTK GYIFLEYASP AHAVDAVKNA DGYKLDKQHT FRVNLFTDFD KYMTISDEWD IPEKQPFKDL GNLRYWLEEA ECRDQYSVIF ESGDRTSIFW NDVKDPVSIE ERARWTETYV RWSPKGTYLA TFHQRGIALW GGEKFKQIQR FSHQGVQLID FSPCERYLVT FSPLMDTQDD PQAIIIWDIL TGHKKRGFHC ESSAHWPIFK WSHDGKFFAR MTLDTLSIYE TPSMGLLDKK SLKISGIKDF SWSPGGNIIA FWVPEDKDIP ARVTLMQLPT RQEIRVRNLF NVVDCKLHWQ KNGDYLCVKV DRTPKGTQGV VTNFEIFRMR EKQVPVDVVE MKETIIAFAW EPNGSKFAVL HGEAPRISVS FYHVKNNGKI ELIKMFDKQQ ANTIFWSPQG QFVVLAGLRS MNGALAFVDT SDCTVMNIAE HYMASDVEWD PTGRYVVTSV SWWSHKVDNA YWLWTFQGRL LQKNNKDRFC QLLWRPRPPT LLSQEQIKQI KKDLKKYSKI FEQKDRLSQS KASKELVERR RTMMEDFRKY RKMAQELYME QKNERLELRG GVDTDELDSN VDDWEEETIE FFVTEEIIPL GNQE
Explore Eukaryotic translation initiation factor 3 subunit B with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets