GDNF family receptor alpha-1 (GFRA1)

About GDNF family receptor alpha-1

GDNF family receptor alpha-1 (GFRA1) is a protein from Homo sapiens identified by UniProt accession P56159, 465 residues long. MolForge cross-references it against 0 known binders and 196 disease associations.

Target properties

Protein name	GDNF family receptor alpha-1
UniProt accession	P56159
Gene	GFRA1
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (196)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.38
bilateral renal agenesis · score 0.37
IGF-1 measurement · score 0.31
insulin like growth factor measurement · score 0.31
glioblastoma multiforme · score 0.30
diet measurement · score 0.28
appendicular lean mass · score 0.26
renal agenesis · score 0.19
neurodegenerative disease · score 0.19
Hirschsprung disease · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56159-F1	alphafold	PREDICTED	74.11	—

Amino-acid sequence (465 residues)

MFLATLYFAL PLLDLLLSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR QCVAGKETNF SLASGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRVVPFISD VFQQVEHIPK GNNCLDAAKA CNLDDICKKY RSAYITPCTT SVSNDVCNRR KCHKALRQFF DKVPAKHSYG MLFCSCRDIA CTERRRQTIV PVCSYEEREK PNCLNLQDSC KTNYICRSRL ADFFTNCQPE SRSVSSCLKE NYADCLLAYS GLIGTVMTPN YIDSSSLSVA PWCDCSNSGN DLEECLKFLN FFKDNTCLKN AIQAFGNGSD VTVWQPAFPV QTTTATTTTA LRVKNKPLGP AGSENEIPTH VLPPCANLQA QKLKSNVSGN THLCISNGNY EKEGLGASSH ITTKSMAAPP SCGLSPLLVL VVTALSTLLS LTETS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards