About Homeobox protein DLX-1
Homeobox protein DLX-1 (DLX1) is a protein
from Homo sapiens identified by UniProt accession
P56177, 255 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Homeobox protein DLX-1 |
|---|
| UniProt accession | P56177 |
|---|
| Gene | DLX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (88)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.14
- platelet count · score 0.10
- neoplasm · score 0.08
- deafness · score 0.08
- lung adenocarcinoma · score 0.07
- papillary thyroid carcinoma · score 0.07
- otosclerosis · score 0.07
- progressive deafness with stapes fixation · score 0.07
- X-linked mixed deafness with perilymphatic gusher · score 0.06
- deafness-ear malformation-facial palsy syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56177-F1 | alphafold | PREDICTED | 64.27 | — |
Amino-acid sequence (255 residues)
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR SKFKKLMKQG GAALEGSALA NGRALSAGSP PVPPGWNPNS SSGKGSGGNA GSYIPSYTSW YPSAHQEAMQ QPQLM
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