Homeobox protein DLX-5 (DLX5)

About Homeobox protein DLX-5

Homeobox protein DLX-5 (DLX5) is a protein from Homo sapiens identified by UniProt accession P56178, 289 residues long. MolForge cross-references it against 0 known binders and 436 disease associations.

Target properties

Protein name	Homeobox protein DLX-5
UniProt accession	P56178
Gene	DLX5
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (436)

Diseases linked to this target (Open Targets).

Split hand-split foot malformation · score 0.66
Split hand - split foot - deafness · score 0.50
split hand-foot malformation 1 with sensorineural hearing loss · score 0.45
heel bone mineral density · score 0.40
neurodegenerative disease · score 0.37
self reported educational attainment · score 0.36
alkaline phosphatase measurement · score 0.33
bone quantitative ultrasound measurement · score 0.32
body height · score 0.32
bone density · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56178-F1	alphafold	PREDICTED	60.68	—

Amino-acid sequence (289 residues)

MTGVFDRRVP SIRSGDFQAP FQTSAAMHHP SQESPTLPES SATDSDYYSP TGGAPHGYCS PTSASYGKAL NPYQYQYHGV NGSAGSYPAK AYADYSYASS YHQYGGAYNR VPSATNQPEK EVTEPEVRMV NGKPKKVRKP RTIYSSFQLA ALQRRFQKTQ YLALPERAEL AASLGLTQTQ VKIWFQNKRS KIKKIMKNGE MPPEHSPSSS DPMACNSPQS PAVWEPQGSS RSLSHHPHAH PPTSNQSPAS SYLENSASWY TSAASSINSH LPPPGSLQHP LALASGTLY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards