About Putative tyrosine-protein phosphatase TPTE
Putative tyrosine-protein phosphatase TPTE (TPTE) is a protein
from Homo sapiens identified by UniProt accession
P56180, 551 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Putative tyrosine-protein phosphatase TPTE |
|---|
| UniProt accession | P56180 |
|---|
| Gene | TPTE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 551 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (112)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.24
- lysosomal storage disease · score 0.24
- multiple sclerosis · score 0.24
- Parkinson disease · score 0.24
- Alzheimer disease · score 0.24
- neurodegenerative disease · score 0.24
- breast adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.19
- squamous cell lung carcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56180-F1 | alphafold | PREDICTED | 81.29 | — |
Amino-acid sequence (551 residues)
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS D
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