Ribosomal RNA processing protein 1 homolog A (RRP1)

About Ribosomal RNA processing protein 1 homolog A

Ribosomal RNA processing protein 1 homolog A (RRP1) is a protein from Homo sapiens identified by UniProt accession P56182, 461 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Ribosomal RNA processing protein 1 homolog A
UniProt accession	P56182
Gene	RRP1
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
cystatin B measurement · score 0.20
blood protein measurement · score 0.16
breast ductal adenocarcinoma · score 0.11
drug use measurement · score 0.11
pyogenic bacterial infections due to MyD88 deficiency · score 0.05
menstrual cycle-dependent periodic fever · score 0.04
hypoparathyroidism · score 0.02
Keloid · score 0.02
age-related macular degeneration · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56182-F1	alphafold	PREDICTED	75.06	—

Amino-acid sequence (461 residues)

MVSRVQLPPE IQLAQRLAGN EQVTRDRAVR KLRKYIVART QRAAGGFTHD ELLKVWKGLF YCMWMQDKPL LQEELGRTIS QLVHAFQTTE AQHLFLQAFW QTMNREWTGI DRLRLDKFYM LMRMVLNESL KVLKMQGWEE RQIEELLELL MTEILHPSSQ APNGVKSHFI EIFLEELTKV GAEELTADQN LKFIDPFCRI AARTKDSLVL NNITRGIFET IVEQAPLAIE DLLNELDTQD EEVASDSDES SEGGERGDAL SQKRSEKPPA GSICRAEPEA GEEQAGDDRD SGGPVLQFDY EAVANRLFEM ASRQSTPSQN RKRLYKVIRK LQDLAGGIFP EDEIPEKACR RLLEGRRQKK TKKQKRLLRL QQERGKGEKE PPSPGMERKR SRRRGVGADP EARAEAGEQP GTAERALLRD QPRGRGQRGA RQRRRTPRPL TSARAKAANV QEPEKKKKRR E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards