About Methionine--tRNA ligase, cytoplasmic
Methionine--tRNA ligase, cytoplasmic (MARS1) is a protein
from Homo sapiens identified by UniProt accession
P56192, 900 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Methionine--tRNA ligase, cytoplasmic |
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| UniProt accession | P56192 |
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| Gene | MARS1 |
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| Organism | Homo sapiens |
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| Length | 900 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- severe early-onset pulmonary alveolar proteinosis due to MARS deficiency · score 0.76
- Charcot-Marie-Tooth disease axonal type 2U · score 0.69
- Acute infantile liver failure-multisystemic involvement syndrome · score 0.66
- spastic paraplegia 70, autosomal recessive · score 0.57
- Autosomal dominant Charcot-Marie-Tooth disease type 2 due to MARS mutation · score 0.55
- autosomal recessive spastic paraplegia type 70 · score 0.37
- pulmonary alveolar proteinosis · score 0.34
- Charcot-Marie-Tooth disease · score 0.19
- triglyceride measurement · score 0.14
- high density lipoprotein cholesterol measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
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| AF-P56192-F1 | alphafold | PREDICTED | 90.29 | — |
Amino-acid sequence (900 residues)
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV LQLDSGNYLF STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL YYLVVQGKKG EDVLGSVRRA LTHIDHSLSR QNCPFLAGET ESLADIVLWG ALYPLLQDPA YLPEELSALH SWFQTLSTQE PCQRAAETVL KQQGVLALRP YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW EKGLESLPPL RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS FDIFGRTTTP QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF VEGVCPFCGY EEARGDQCDK CGKLINAVEL KKPQCKVCRS CPVVQSSQHL FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF ITRSWLRDGL KPRCITRDLK WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW KNPEQVDLYQ FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL GNFINRAGMF VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR IRDALRSILT ISRHGNQYIQ VNEPWKRIKG SEADRQRAGT VTGLAVNIAA LLSVMLQPYM PTVSATIQAQ LQLPPPACSI LLTNFLCTLP AGHQIGTVSP LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ QIQALMDEVT KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK
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