Myc-associated zinc finger protein (MAZ)

About Myc-associated zinc finger protein

Myc-associated zinc finger protein (MAZ) is a protein from Homo sapiens identified by UniProt accession P56270, 477 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	Myc-associated zinc finger protein
UniProt accession	P56270
Gene	MAZ
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (105)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.35
hepatocellular carcinoma · score 0.09
nonpapillary renal cell carcinoma · score 0.08
mean platelet volume · score 0.08
pachyonychia congenita · score 0.07
neoplasm · score 0.06
triple-negative breast cancer · score 0.06
cancer · score 0.05
Ochoa syndrome · score 0.04
fetal lower urinary tract obstruction · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56270-F1	alphafold	PREDICTED	58.62	—

Amino-acid sequence (477 residues)

MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS RFFASQGCAQ SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA AAAAAAAAVA AAPPAPAAAS TVDTAALKQP PAPPPPPPPV SAPAAEAAPP ASAATIAAAA ATAVVAPTST VAVAPVASAL EKKTKSKGPY ICALCAKEFK NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ LSGAGGGGGE AGAGGGAAAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD HLNSHVRQVH STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM LSSAYISDHM KVHSQGPHHV CELCNKGTGE VCPMAAAAAA AAAAAAAAVA APPTAVGSLS GAEGVPVSSQ PLPSQPW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards