T-cell leukemia/lymphoma protein 1A (TCL1A)

About T-cell leukemia/lymphoma protein 1A

T-cell leukemia/lymphoma protein 1A (TCL1A) is a protein from Homo sapiens identified by UniProt accession P56279, 114 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	T-cell leukemia/lymphoma protein 1A
UniProt accession	P56279
Gene	TCL1A
Organism	Homo sapiens
Length	114 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
platelet count · score 0.45
mosaic loss of chromosome Y measurement · score 0.44
chronic lymphocytic leukemia · score 0.38
lymphoid neoplasm · score 0.37
prostate neuroendocrine neoplasm · score 0.37
cutaneous melanoma · score 0.37
platelet crit · score 0.37
diffuse large B-cell lymphoma · score 0.33
oral squamous cell carcinoma · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56279-F1	alphafold	PREDICTED	90.13	—

Amino-acid sequence (114 residues)

MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards