DNA polymerase epsilon subunit 2 (POLE2)

About DNA polymerase epsilon subunit 2

DNA polymerase epsilon subunit 2 (POLE2) is a protein from Homo sapiens identified by UniProt accession P56282, 527 residues long. MolForge cross-references it against 0 known binders and 338 disease associations.

Target properties

Protein name	DNA polymerase epsilon subunit 2
UniProt accession	P56282
Gene	POLE2
Organism	Homo sapiens
Length	527 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (338)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.60
acute myeloid leukemia · score 0.60
acute lymphoblastic leukemia · score 0.60
ovarian cancer · score 0.60
pancreatic carcinoma · score 0.59
chronic lymphocytic leukemia · score 0.59
ovarian carcinoma · score 0.57
breast carcinoma · score 0.57
neoplasm · score 0.57
adult acute lymphoblastic leukemia · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56282-F1	alphafold	PREDICTED	92.98	—

Amino-acid sequence (527 residues)

MAPERLRSRA LSAFKLRGLL LRGEAIKYLT EALQSISELE LEDKLEKIIN AVEKQPLSSN MIERSVVEAA VQECSQSVDE TIEHVFNIIG AFDIPRFVYN SERKKFLPLL MTNHPAPNLF GTPRDKAEMF RERYTILHQR THRHELFTPP VIGSHPDESG SKFQLKTIET LLGSTTKIGD AIVLGMITQL KEGKFFLEDP TGTVQLDLSK AQFHSGLYTE ACFVLAEGWF EDQVFHVNAF GFPPTEPSST TRAYYGNINF FGGPSNTSVK TSAKLKQLEE ENKDAMFVFL SDVWLDQVEV LEKLRIMFAG YSPAPPTCFI LCGNFSSAPY GKNQVQALKD SLKTLADIIC EYPDIHQSSR FVFVPGPEDP GFGSILPRPP LAESITNEFR QRVPFSVFTT NPCRIQYCTQ EITVFREDLV NKMCRNCVRF PSSNLAIPNH FVKTILSQGH LTPLPLYVCP VYWAYDYALR VYPVPDLLVI ADKYDPFTTT NTECLCINPG SFPRSGFSFK VFYPSNKTVE DSKLQGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards