AP-1 complex subunit sigma-2 (AP1S2)

About AP-1 complex subunit sigma-2

AP-1 complex subunit sigma-2 (AP1S2) is a protein from Homo sapiens identified by UniProt accession P56377, 157 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	AP-1 complex subunit sigma-2
UniProt accession	P56377
Gene	AP1S2
Organism	Homo sapiens
Length	157 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

syndromic X-linked intellectual disability 5 · score 0.79
X-linked intellectual disability - Dandy-Walker malformation - basal ganglia disease - Seizures · score 0.64
HIV infection · score 0.50
genetic disorder · score 0.38
X-linked syndromic intellectual disability · score 0.37
fried syndrome · score 0.37
Dystonia · score 0.37
ovarian carcinoma · score 0.16
melanoma · score 0.08
multiple symmetric lipomatosis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56377-F1	alphafold	PREDICTED	94.09	—

Amino-acid sequence (157 residues)

MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards