ATP synthase F(1) complex subunit epsilon…

About ATP synthase F(1) complex subunit epsilon, mitochondrial

ATP synthase F(1) complex subunit epsilon, mitochondrial (ATP5F1E) is a protein from Homo sapiens identified by UniProt accession P56381, 51 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	ATP synthase F(1) complex subunit epsilon, mitochondrial
UniProt accession	P56381
Gene	ATP5F1E
Organism	Homo sapiens
Length	51 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (116)

Diseases linked to this target (Open Targets).

Isolated ATP synthase deficiency · score 0.50
mitochondrial complex V (ATP synthase) deficiency nuclear type 3 · score 0.46
type 2 diabetes mellitus · score 0.23
diabetes mellitus · score 0.22
mean platelet volume · score 0.21
obesity · score 0.17
complication · score 0.15
platelet count · score 0.11
Blackfan-Diamond anemia · score 0.09
alpha thalassemia-intellectual disability syndrome type 1 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56381-F1	alphafold	PREDICTED	86.10	—

Amino-acid sequence (51 residues)

MVAYWRQAGL SYIRYSQICA KAVRDALKTE FKANAEKTSG SNVKIVKVKK E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

ATP synthase F(1) complex subunit epsilon, mitochondrial (ATP5F1E)