About Eukaryotic translation initiation factor 6
Eukaryotic translation initiation factor 6 (EIF6) is a protein
from Homo sapiens identified by UniProt accession
P56537, 245 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 6 |
|---|
| UniProt accession | P56537 |
|---|
| Gene | EIF6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (148)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.40
- reticulocyte measurement · score 0.20
- sunburn · score 0.16
- Immature Reticulocyte Fraction Measurement · score 0.16
- neurodegenerative disease · score 0.15
- exstrophy-epispadias complex · score 0.12
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.09
- freckles · score 0.08
- oral squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56537-F1 | alphafold | PREDICTED | 91.02 | — |
Amino-acid sequence (245 residues)
MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL IDSLT
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