C-terminal-binding protein 2 (CTBP2)

About C-terminal-binding protein 2

C-terminal-binding protein 2 (CTBP2) is a protein from Homo sapiens identified by UniProt accession P56545, 445 residues long. MolForge cross-references it against 0 known binders and 171 disease associations.

Target properties

Protein name	C-terminal-binding protein 2
UniProt accession	P56545
Gene	CTBP2
Organism	Homo sapiens
Length	445 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (171)

Diseases linked to this target (Open Targets).

age at menarche · score 0.45
erythrocyte count · score 0.42
diet measurement · score 0.41
cortical surface area measurement · score 0.40
neuroimaging measurement · score 0.39
body mass index · score 0.39
sensorineural hearing loss · score 0.39
hearing loss · score 0.39
age-related hearing impairment · score 0.39
chronotype measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56545-F1	alphafold	PREDICTED	83.36	—

Amino-acid sequence (445 residues)

MALVDKHKVK RQRLDRICEG IRPQIMNGPL HPRPLVALLD GRDCTVEMPI LKDLATVAFC DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRV IVRIGSGYDN VDIKAAGELG IAVCNIPSAA VEETADSTIC HILNLYRRNT WLYQALREGT RVQSVEQIRE VASGAARIRG ETLGLIGFGR TGQAVAVRAK AFGFSVIFYD PYLQDGIERS LGVQRVYTLQ DLLYQSDCVS LHCNLNEHNH HLINDFTIKQ MRQGAFLVNA ARGGLVDEKA LAQALKEGRI RGAALDVHES EPFSFAQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP ESLRNCVNKE FFVTSAPWSV IDQQAIHPEL NGATYRYPPG IVGVAPGGLP AAMEGIIPGG IPVTHNLPTV AHPSQAPSPN QPTKHGDNRE HPNEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards