Peroxisomal biogenesis factor 3 (PEX3)

About Peroxisomal biogenesis factor 3

Peroxisomal biogenesis factor 3 (PEX3) is a protein from Homo sapiens identified by UniProt accession P56589, 373 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Peroxisomal biogenesis factor 3
UniProt accession	P56589
Gene	PEX3
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 10A (Zellweger) · score 0.76
Zellweger syndrome · score 0.73
peroxisome biogenesis disorder · score 0.57
neurodegenerative disease · score 0.50
peroxisome biogenesis disorder 1A (Zellweger) · score 0.44
Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.44
peroxisome biogenesis disorder, complementation group 7 · score 0.37
genetic disorder · score 0.18
cutaneous melanoma · score 0.13
PHF-tau measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56589-F1	alphafold	PREDICTED	88.88	—

Amino-acid sequence (373 residues)

MLRSVWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKNRPSNK LEIWEDLKII SFTRSTVAVY STCMLVVLLR VQLNIIGGYI YLDNAAVGKN GTTILAPPDV QQQYLSSIQH LLGDGLTELI TVIKQAVQKV LGSVSLKHSL SLLDLEQKLK EIRNLVEQHK SSSWINKDGS KPLLCHYMMP DEETPLAVQA CGLSPRDITT IKLLNETRDM LESPDFSTVL NTCLNRGFSR LLDNMAEFFR PTEQDLQHGN SMNSLSSVSL PLAKIIPIVN GQIHSVCSET PSHFVQDLLT MEQVKDFAAN VYEAFSTPQQ LEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards