Proto-oncogene Wnt-3 (WNT3)

About Proto-oncogene Wnt-3

Proto-oncogene Wnt-3 (WNT3) is a protein from Homo sapiens identified by UniProt accession P56703, 355 residues long. MolForge cross-references it against 0 known binders and 216 disease associations.

Target properties

Protein name	Proto-oncogene Wnt-3
UniProt accession	P56703
Gene	WNT3
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (216)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
Tetraamelia - multiple malformations · score 0.45
erythrocyte count · score 0.42
tetraamelia-multiple malformations syndrome · score 0.37
Parkinson disease · score 0.34
cognitive function measurement · score 0.34
mean platelet volume · score 0.33
snoring measurement · score 0.32
total cortical area measurement · score 0.32
blood protein measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P56703-F1	alphafold	PREDICTED	88.27	—

Amino-acid sequence (355 residues)

MEPHLLGLLL GLLLGGTRVL AGYPIWWSLA LGQQYTSLGS QPLLCGSIPG LVPKQLRFCR NYIEIMPSVA EGVKLGIQEC QHQFRGRRWN CTTIDDSLAI FGPVLDKATR ESAFVHAIAS AGVAFAVTRS CAEGTSTICG CDSHHKGPPG EGWKWGGCSE DADFGVLVSR EFADARENRP DARSAMNKHN NEAGRTTILD HMHLKCKCHG LSGSCEVKTC WWAQPDFRAI GDFLKDKYDS ASEMVVEKHR ESRGWVETLR AKYSLFKPPT ERDLVYYENS PNFCEPNPET GSFGTRDRTC NVTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECIRIYD VHTCK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards