About Protein Wnt-4
Protein Wnt-4 (WNT4) is a protein
from Homo sapiens identified by UniProt accession
P56705, 351 residues long.
MolForge cross-references it against 0 known binders and
319 disease associations.
Target properties
| Protein name | Protein Wnt-4 |
|---|
| UniProt accession | P56705 |
|---|
| Gene | WNT4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 351 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (319)
Diseases linked to this target (Open Targets).
- mullerian aplasia and hyperandrogenism · score 0.68
- SERKAL syndrome · score 0.59
- Mayer-Rokitansky-Küster-Hauser syndrome · score 0.56
- heel bone mineral density · score 0.49
- body height · score 0.45
- uterine fibroid · score 0.43
- endometriosis · score 0.42
- bone density · score 0.41
- lean body mass · score 0.40
- BMI-adjusted hip circumference · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56705-F1 | alphafold | PREDICTED | 91.09 | — |
Amino-acid sequence (351 residues)
MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI QRQVQMCKRN LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK VVTQGTREAA FVYAISSAGV AFAVTRACSS GELEKCGCDR TVHGVSPQGF QWSGCSDNIA YGVAFSQSFV DVRERSKGAS SSRALMNLHN NEAGRKAILT HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG ATEVEPRRVG SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDMRSGVLG TRGRTCNKTS KAIDGCELLC CGRGFHTAQV ELAERCSCKF HWCCFVKCRQ CQRLVELHTC R
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