About Claudin-6
Claudin-6 (CLDN6) is a protein
from Homo sapiens identified by UniProt accession
P56747, 220 residues long.
MolForge cross-references it against 0 known binders and
127 disease associations.
Target properties
| Protein name | Claudin-6 |
|---|
| UniProt accession | P56747 |
|---|
| Gene | CLDN6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 220 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (127)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.16
- head and neck squamous cell carcinoma · score 0.15
- neoplasm · score 0.11
- cancer · score 0.10
- breast cancer · score 0.10
- non-small cell lung carcinoma · score 0.09
- urinary bladder carcinoma · score 0.08
- esophageal adenocarcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56747-F1 | alphafold | PREDICTED | 80.22 | — |
Amino-acid sequence (220 residues)
MASAGMQILG VVLTLLGWVN GLVSCALPMW KVTAFIGNSI VVAQVVWEGL WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVIALLV ALFGLLVYLA GAKCTTCVEE KDSKARLVLT SGIVFVISGV LTLIPVCWTA HAIIRDFYNP LVAEAQKREL GASLYLGWAA SGLLLLGGGL LCCTCPSGGS QGPSHYMARY STSAPAISRG PSEYPTKNYV
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