About Claudin-8
Claudin-8 (CLDN8) is a protein
from Homo sapiens identified by UniProt accession
P56748, 225 residues long.
MolForge cross-references it against 0 known binders and
96 disease associations.
Target properties
| Protein name | Claudin-8 |
|---|
| UniProt accession | P56748 |
|---|
| Gene | CLDN8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 225 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (96)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.37
- cystatin C measurement · score 0.28
- uric acid measurement · score 0.27
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.23
- nonpapillary renal cell carcinoma · score 0.08
- smoking status measurement · score 0.07
- clear cell renal carcinoma · score 0.07
- inflammatory bowel disease · score 0.06
- papillary renal cell carcinoma · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56748-F1 | alphafold | PREDICTED | 80.45 | — |
Amino-acid sequence (225 residues)
MATHALEIAG LFLGGVGMVG TVAVTVMPQW RVSAFIENNI VVFENFWEGL WMNCVRQANI RMQCKIYDSL LALSPDLQAA RGLMCAASVM SFLAFMMAIL GMKCTRCTGD NEKVKAHILL TAGIIFIITG MVVLIPVSWV ANAIIRDFYN SIVNVAQKRE LGEALYLGWT TALVLIVGGA LFCCVFCCNE KSSSYRYSIP SHRTTQKSYH TGKKSPSVYS RSQYV
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