About Claudin-12
Claudin-12 (CLDN12) is a protein
from Homo sapiens identified by UniProt accession
P56749, 244 residues long.
MolForge cross-references it against 0 known binders and
67 disease associations.
Target properties
| Protein name | Claudin-12 |
|---|
| UniProt accession | P56749 |
|---|
| Gene | CLDN12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 244 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- FEV/FVC ratio · score 0.26
- breast adenocarcinoma · score 0.25
- endometrial cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.15
- gastric adenocarcinoma · score 0.09
- attention deficit hyperactivity disorder · score 0.06
- Tourette syndrome · score 0.05
- schizophrenia 15 · score 0.05
- attention deficit-hyperactivity disorder 8 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56749-F1 | alphafold | PREDICTED | 81.05 | — |
Amino-acid sequence (244 residues)
MGCRDVHAAT VLSFLCGIAS VAGLFAGTLL PNWRKLRLIT FNRNEKNLTV YTGLWVKCAR YDGSSDCLMY DTTWYSSVDQ LDLRVLQFAL PLSMLIAMGA LLLCLIGMCN TAFRSSVPNI KLAKCLVNSA GCHLVAGLLF FLAGTVSLSP SIWVIFYNIH LNKKFEPVFS FDYAVYVTIA SAGGLFMTSL ILFIWYCTCK SLPSPFWQPL YSHPPSMHTY SQPYSARSRL SAIEIDIPVV SHTT
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