About Claudin-18
Claudin-18 (CLDN18) is a protein
from Homo sapiens identified by UniProt accession
P56856, 261 residues long.
MolForge cross-references it against 0 known binders and
200 disease associations.
Target properties
| Protein name | Claudin-18 |
|---|
| UniProt accession | P56856 |
|---|
| Gene | CLDN18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 261 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (200)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.41
- endometrial cancer · score 0.23
- glioblastoma multiforme · score 0.16
- head and neck squamous cell carcinoma · score 0.15
- Aganglionic megacolon · score 0.12
- neoplasm · score 0.10
- gastric adenocarcinoma · score 0.10
- pancreatic adenocarcinoma · score 0.09
- hepatocellular carcinoma · score 0.08
- Barrett's esophagus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56856-F1 | alphafold | PREDICTED | 72.81 | — |
Amino-acid sequence (261 residues)
MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW RSCVRQSSGF TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA LKCIRIGSME DSAKANMTLT SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS TANMYTGMGG MVQTVQTRYT FGAALFVGWV AGGLTLIGGV MMCIACRGLA PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI YDGGARTEDE VQSYPSKHDY V
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