About Pro-neuregulin-3, membrane-bound isoform
Pro-neuregulin-3, membrane-bound isoform (NRG3) is a protein
from Homo sapiens identified by UniProt accession
P56975, 720 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Pro-neuregulin-3, membrane-bound isoform |
|---|
| UniProt accession | P56975 |
|---|
| Gene | NRG3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 720 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- cancer · score 0.58
- neurodegenerative disease · score 0.37
- kidney cancer · score 0.34
- kidney neoplasm · score 0.33
- Hirschsprung disease · score 0.31
- diet measurement · score 0.31
- Aganglionic megacolon · score 0.31
- adolescent idiopathic scoliosis · score 0.30
- breast adenocarcinoma · score 0.30
- body mass index · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56975-F1 | alphafold | PREDICTED | 50.13 | — |
Amino-acid sequence (720 residues)
MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPTDHLGIEF MESEEVYQRQ VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS STMAKSENLV KSHVQLQNYS KVERHPVTAL EKMMESSFVG PQSFPEVPSP DRGSQSVKHH RSLSSCCSPG QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPD QDTIPCQGIE VRKTISHLPI QLWCVERPLD LKYSSSGLKT QRNTSINMQL PSRETNPYFN SLEQKDLVGY SSTRASSVPI IPSVGLEETC LQMPGISEVK SIKWCKNSYS ADVVNVSIPV SDCLIAEQQE VKILLETVQE QIRILTDARR SEDYELASVE TEDSASENTA FLPLSPTAKS EREAQFVLRN EIQRDSALTK
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