Histone H2B type F-S (H2BC12L)

About Histone H2B type F-S

Histone H2B type F-S (H2BC12L) is a protein from Homo sapiens identified by UniProt accession P57053, 126 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Histone H2B type F-S
UniProt accession	P57053
Gene	H2BC12L
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

cancer · score 0.37
melanoma · score 0.37
breast carcinoma · score 0.37
hypertension · score 0.06
mean corpuscular volume · score 0.06
systolic blood pressure · score 0.05
mean corpuscular hemoglobin · score 0.05
cardiovascular disease · score 0.04
diastolic blood pressure · score 0.04
chronic obstructive pulmonary disease · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57053-F1	alphafold	PREDICTED	86.18	—

Amino-acid sequence (126 residues)

MPEPAKSAPA PKKGSKKAVT KAQKKDGRKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LPHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards