About Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) is a protein
from Homo sapiens identified by UniProt accession
P57054, 158 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P |
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| UniProt accession | P57054 |
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| Gene | PIGP |
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| Organism | Homo sapiens |
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| Length | 158 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (31)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 55 · score 0.61
- developmental and epileptic encephalopathy · score 0.54
- neurodegenerative disease · score 0.32
- genetic disorder · score 0.19
- multiple congenital anomalies-hypotonia-seizures syndrome · score 0.18
- appendicular lean mass · score 0.18
- body height · score 0.11
- eye color · score 0.08
- IGF-1 measurement · score 0.06
- hemoglobin measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57054-F1 | alphafold | PREDICTED | 82.27 | — |
Amino-acid sequence (158 residues)
MVPRSTSLTL IVFLFHRLSK APGKMVENSP SPLPERAIYG FVLFLSSQFG FILYLVWAFI PESWLNSLGL TYWPQKYWAV ALPVYLLIAI VIGYVLLFGI NMMSTSPLDS IHTITDNYAK NQQQKKYQEE AIPALRDISI SEVNQMFFLA AKELYTKN
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