Glucose-6-phosphate exchanger SLC37A1 (SLC37A1)

About Glucose-6-phosphate exchanger SLC37A1

Glucose-6-phosphate exchanger SLC37A1 (SLC37A1) is a protein from Homo sapiens identified by UniProt accession P57057, 533 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Glucose-6-phosphate exchanger SLC37A1
UniProt accession	P57057
Gene	SLC37A1
Organism	Homo sapiens
Length	533 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.38
fat body mass · score 0.33
lean body mass · score 0.29
self reported educational attainment · score 0.21
body mass index · score 0.21
red blood cell density measurement · score 0.15
genetic disorder · score 0.12
erythrocyte count · score 0.07
SAPHO syndrome · score 0.05
Crigler-Najjar syndrome type 2 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57057-F1	alphafold	PREDICTED	79.50	—

Amino-acid sequence (533 residues)

MARLPAGIRF IISFSRDQWY RAFIFILTFL LYASFHLSRK PISIVKGELH KYCTAWDEAD VRFSSQNRKS GSAAPHQLPD NETDCGWAPF DKNNYQQLLG ALDYSFLCAY AVGMYLSGII GERLPIRYYL TFGMLASGAF TALFGLGYFY NIHSFGFYVV TQVINGLVQT TGWPSVVTCL GNWFGKGRRG LIMGVWNSHT SVGNILGSLI AGYWVSTCWG LSFVVPGAIV AAMGIVCFLF LIEHPNDVRC SSTLVTHSKG YENGTNRLRL QKQILKSEKN KPLDPEMQCL LLSDGKGSIH PNHVVILPGD GGSGTAAISF TGALKIPGVI EFSLCLLFAK LVSYTFLFWL PLYITNVDHL DAKKAGELST LFDVGGIFGG ILAGVISDRL EKRASTCGLM LLLAAPTLYI FSTVSKMGLE ATIAMLLLSG ALVSGPYTLI TTAVSADLGT HKSLKGNAHA LSTVTAIIDG TGSVGAALGP LLAGLLSPSG WSNVFYMLMF ADACALLFLI RLIHKELSCP GSATGDQVPF KEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards