About Hormonally up-regulated neu tumor-associated kinase
Hormonally up-regulated neu tumor-associated kinase (HUNK) is a protein
from Homo sapiens identified by UniProt accession
P57058, 714 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Hormonally up-regulated neu tumor-associated kinase |
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| UniProt accession | P57058 |
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| Gene | HUNK |
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| Organism | Homo sapiens |
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| Length | 714 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (90)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- joint damage measurement · score 0.27
- protein measurement · score 0.21
- breast cancer · score 0.10
- neoplasm · score 0.10
- substance abuse · score 0.08
- antisocial behaviour measurement · score 0.08
- attention deficit hyperactivity disorder · score 0.08
- drug use measurement · score 0.08
- Arrhythmogenic right ventricular dysplasia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57058-F1 | alphafold | PREDICTED | 61.99 | — |
Amino-acid sequence (714 residues)
MPAAAGDGLL GEPAAPGGGG GAEDAARPAA ACEGSFLPAW VSGVPRERLR DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH KIYEKKRLEE SEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG VNMYAMLTGT LPFTVEPFSL RALYQKMVDK EMNPLPTQLS TGAISFLRSL LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSLC YKTRLYQIEK YRAPKESYEA SLDTWTRDLE FHAVQDKKPK EQEKRGDFLH RPFSKKLDKN LPSHKQPSGS LMTQIQNTKA LLKDRKASKS SFPDKDSFGC RNIFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKPEPHQP GPGSTGIPHK EDPLMLDMVR SFESVDRDDH VEVLSPSHHY RILNSPVSLA RRNSSERTLS PGLPSGSMSP LHTPLHPTLV SFAHEDKNSP PKEEGLCCPP PVPSNGPMQP LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSADRPLEAS LPPLQPLAPV NLAFDMADGV KTQC
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