RWD domain-containing protein 2B (RWDD2B)

About RWD domain-containing protein 2B

RWD domain-containing protein 2B (RWDD2B) is a protein from Homo sapiens identified by UniProt accession P57060, 319 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	RWD domain-containing protein 2B
UniProt accession	P57060
Gene	RWDD2B
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.24
electrocardiography · score 0.20
reticulocyte count · score 0.20
serum alanine aminotransferase measurement · score 0.18
body mass index · score 0.17
aspartate aminotransferase to alanine aminotransferase ratio · score 0.16
body height · score 0.11
body weight · score 0.08
reticulocyte measurement · score 0.07
Immature Reticulocyte Fraction Measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57060-F1	alphafold	PREDICTED	81.22	—

Amino-acid sequence (319 residues)

MKIELSMQPW NPGYSSEGAT AQETYTCPKM IEMEQAEAQL AELDLLASMF PGENELIVND QLAVAELKDC IEKKTMEGRS SKVYFTINMN LDVSDEKMAM FSLACILPFK YPAVLPEITV RSVLLSRSQQ TQLNTDLTAF LQKHCHGDVC ILNATEWVRE HASGYVSRDT SSSPTTGSTV QSVDLIFTRL WIYSHHIYNK CKRKNILEWA KELSLSGFSM PGKPGVVCVE GPQSACEEFW SRLRKLNWKR ILIRHREDIP FDGTNDETER QRKFSIFEEK VFSVNGARGN HMDFGQLYQF LNTKGCGDVF QMFFGVEGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards