About PR domain zinc finger protein 15
PR domain zinc finger protein 15 (PRDM15) is a protein
from Homo sapiens identified by UniProt accession
P57071, 1141 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | PR domain zinc finger protein 15 |
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| UniProt accession | P57071 |
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| Gene | PRDM15 |
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| Organism | Homo sapiens |
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| Length | 1141 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- Rare pervasive developmental disorder · score 0.27
- pervasive developmental disorder · score 0.27
- insomnia measurement · score 0.25
- mean corpuscular hemoglobin concentration · score 0.21
- protein measurement · score 0.20
- a disintegrin and metalloproteinase with thrombospondin motifs 13 measurement · score 0.20
- steroid-resistant nephrotic syndrome · score 0.18
- myeloid white cell count · score 0.09
- cholangiocarcinoma · score 0.07
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57071-F1 | alphafold | PREDICTED | 56.01 | — |
Amino-acid sequence (1141 residues)
MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSSLPPN LEIRRLEDGA EGVFAITQLV KRTQFGPFES RRVAKWEKES AFPLKVFQKD GHPVCFDTSN EDDCNWMMLV RPAAEAEHQN LTAYQHGSDV YFTTSRDIPP GTELRVWYAA FYAKKMDKPM LKQAGSGVHA AGTPENSAPV ESEPSQWACK VCSATFLELQ LLNEHLLGHL EQAKSLPPGS QSEAAAPEKE QDTPRGEPPA VPESENVATK EQKKKPRRGR KPKVSKAEQP LVIVEDKEPT EQVAEIITEV PPDEPVSATP DERIMELVLG KLATTTTDTS SVPKFTHHQN NTITLKRSLI LSSRHGIRRK LIKQLGEHKR VYQCNICSKI FQNSSNLSRH VRSHGDKLFK CEECAKLFSR KESLKQHVSY KHSRNEVDGE YRYRCGTCEK TFRIESALEF HNCRTDDKTF QCEMCFRFFS TNSNLSKHKK KHGDKKFACE VCSKMFYRKD VMLDHQRRHL EGVRRVKRED LEAGGENLVR YKKEPSGCPV CGKVFSCRSN MNKHLLTHGD KKYTCEICGR KFFRVDVLRD HIHVHFKDIA LMDDHQREEF IGKIGISSEE NDDNSDESAD SEPHKYSCKR CQLTFGRGKE YLKHIMEVHK EKGYGCSICN RRFALKATYH AHMVIHRENL PDPNVQKYIH PCEICGRIFN SIGNLERHKL IHTGVKSHAC EQCGKSFARK DMLKEHMRVH DNVREYLCAE CGKGMKTKHA LRHHMKLHKG IKEYECKECH RRFAQKVNML KHCKRHTGIK DFMCELCGKT FSERNTMETH KLIHTVGKQW TCSVCDKKYV TEYMLQKHVQ LTHDKVEAQS CQLCGTKVST RASMSRHMRR KHPEVLAVRI DDLDHLPETT TIDASSIGIV QPELTLEQED LAEGKHGKAA KRSHKRKQKP EEEAGAPVPE DATFSEYSEK ETEFTGSVGD ETNSAVQSIQ QVVVTLGDPN VTTPSSSVGL TNITVTPITT AAATQFTNLQ PVAVGHLTTP ERQLQLDNSI LTVTFDTVSG SAMLHNRQND VQIHPQPEAS NPQSVAHFIN LTTLVNSITP LGSQLSDQHP LTWRAVPQTD VLPPSQPQAP PQQAAQPQVQ AEQQQQQMYS Y
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