About Ubiquitin-associated and SH3 domain-containing protein A
Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) is a protein
from Homo sapiens identified by UniProt accession
P57075, 661 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Ubiquitin-associated and SH3 domain-containing protein A |
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| UniProt accession | P57075 |
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| Gene | UBASH3A |
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| Organism | Homo sapiens |
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| Length | 661 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- type 1 diabetes mellitus · score 0.48
- eosinophil count · score 0.43
- rheumatoid arthritis · score 0.41
- lymphocyte count · score 0.38
- celiac disease · score 0.37
- Thyroid preparation use measurement · score 0.36
- hypothyroidism · score 0.36
- Vitiligo · score 0.35
- sclerosing cholangitis · score 0.35
- autoimmune disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57075-F1 | alphafold | PREDICTED | 82.24 | — |
Amino-acid sequence (661 residues)
MAAGETQLYA KVSNKLKSRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA SLLAGTSVSR FWIFSQVPGH GPNLRLSNLT RASFVSHYIL QKYCSVKPCT KQLHLTLAHK FYPHHQRTLE QLARAIPLGH SCQWTAALYS RDMRFVHYQT LRALFQYKPQ NVDELTLSPG DYIFVDPTQQ DEASEGWVIG ISQRTGCRGF LPENYTDRAS ESDTWVKHRM YTFSLATDLN SRKDGEASSR CSGEFLPQTA RSLSSLQALQ ATVARKSVLV VRHGERVDQI FGKAWLQQCS TPDGKYYRPD LNFPCSLPRR SRGIKDFEND PPLSSCGIFQ SRIAGDALLD SGIRISSVFA SPALRCVQTA KLILEELKLE KKIKIRVEPG IFEWTKWEAG KTTPTLMSLE ELKEANFNID TDYRPAFPLS ALMPAESYQE YMDRCTASMV QIVNTCPQDT GVILIVSHGS TLDSCTRPLL GLPPRECGDF AQLVRKIPSL GMCFCEENKE EGKWELVNPP VKTLTHGANA AFNWRNWISG N
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