Cilia- and flagella-associated protein 298 (CFAP298)

About Cilia- and flagella-associated protein 298

Cilia- and flagella-associated protein 298 (CFAP298) is a protein from Homo sapiens identified by UniProt accession P57076, 290 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Cilia- and flagella-associated protein 298
UniProt accession	P57076
Gene	CFAP298
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

primary ciliary dyskinesia · score 0.66
Heterotaxy · score 0.33
genetic disorder · score 0.16
blood protein measurement · score 0.04
body height · score 0.02
obstructive sleep apnea · score 0.02
Down syndrome · score 0.01
allergic rhinitis · score 0.01
atrial fibrillation · score 0.01
chronic kidney disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57076-F1	alphafold	PREDICTED	86.50	—

Amino-acid sequence (290 residues)

MVLLHVKRGD ESQFLLQAPG STELEELTVQ VARVYNGRLK VQRLCSEMEE LAEHGIFLPP NMQGLTDDQI EELKLKDEWG EKCVPSGGAV FKKDDIGRRN GQAPNEKMKQ VLKKTIEEAK AIISKKQVEA GVCVTMEMVK DALDQLRGAV MIVYPMGLPP YDPIRMEFEN KEDLSGTQAG LNVIKEAEAQ LWWAAKELRR TKKLSDYVGK NEKTKIIAKI QQRGQGAPAR EPIISSEEQK QLMLYYHRRQ EELKRLEEND DDAYLNSPWA DNTALKRHFH GVKDIKWRPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards