About tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WDR4) is a protein
from Homo sapiens identified by UniProt accession
P57081, 412 residues long.
MolForge cross-references it against 0 known binders and
107 disease associations.
Target properties
| Protein name | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 |
|---|
| UniProt accession | P57081 |
|---|
| Gene | WDR4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 412 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (107)
Diseases linked to this target (Open Targets).
- microcephaly, growth deficiency, seizures, and brain malformations · score 0.65
- Galloway-Mowat syndrome · score 0.63
- genetic disorder · score 0.41
- Abnormality of the digestive system · score 0.14
- hepatocellular carcinoma · score 0.10
- cancer · score 0.08
- acute myeloid leukemia · score 0.08
- esophageal squamous cell carcinoma · score 0.08
- urinary bladder carcinoma · score 0.07
- head and neck squamous cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57081-F1 | alphafold | PREDICTED | 86.53 | — |
Amino-acid sequence (412 residues)
MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN KGEDAPLDQG SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT VARRCTALTF IASEEKVLVA DKSGDVYSFS VLEPHGCGRL ELGHLSMLLD VAVSPDDRFI LTADRDEKIR VSWAAAPHSI ESFCLGHTEF VSRISVVPTQ PGLLLSSSGD GTLRLWEYRS GRQLHCCHLA SLQELVDPQA PQKFAASRIA FWCQENCVAL LCDGTPVVYI FQLDARRQQL VYRQQLAFQH QVWDVAFEET QGLWVLQDCQ EAPLVLYRPV GDQWQSVPES TVLKKVSGVL RGNWAMLEGS AGADASFSSL YKATFDNVTS YLKKKEERLQ QQLEKKQRRR SPPPGPDGHA KKMRPGEATL SC
Explore tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets