About T-box transcription factor TBX4
T-box transcription factor TBX4 (TBX4) is a protein
from Homo sapiens identified by UniProt accession
P57082, 545 residues long.
MolForge cross-references it against 0 known binders and
401 disease associations.
Target properties
| Protein name | T-box transcription factor TBX4 |
|---|
| UniProt accession | P57082 |
|---|
| Gene | TBX4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 545 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (401)
Diseases linked to this target (Open Targets).
- coxopodopatellar syndrome · score 0.79
- autosomal recessive amelia · score 0.55
- pulmonary hypertension, primary, 1 · score 0.53
- pulmonary arterial hypertension · score 0.50
- Pulmonary arterial hypertension associated with congenital heart disease · score 0.38
- heritable pulmonary arterial hypertension · score 0.37
- body height · score 0.37
- Pulmonary hypoplasia · score 0.34
- Abnormality of prenatal development or birth · score 0.34
- Hydroureter · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57082-F1 | alphafold | PREDICTED | 60.15 | — |
Amino-acid sequence (545 residues)
MLQDKGLSES EEAFRAPGPA LGEASAANAP EPALAAPGLS GAALGSPPGP GADVVAAAAA EQTIENIKVG LHEKELWKKF HEAGTEMIIT KAGRRMFPSY KVKVTGMNPK TKYILLIDIV PADDHRYKFC DNKWMVAGKA EPAMPGRLYV HPDSPATGAH WMRQLVSFQK LKLTNNHLDP FGHIILNSMH KYQPRLHIVK ADENNAFGSK NTAFCTHVFP ETSFISVTSY QNHKITQLKI ENNPFAKGFR GSDDSDLRVA RLQSKEYPVI SKSIMRQRLI SPQLSATPDV GPLLGTHQAL QHYQHENGAH SQLAEPQDLP LSTFPTQRDS SLFYHCLKRR DGTRHLDLPC KRSYLEAPSS VGEDHYFRSP PPYDQQMLSP SYCSEVTPRE ACMYSGSGPE IAGVSGVDDL PPPPLSCNMW TSVSPYTSYS VQTMETVPYQ PFPTHFTATT MMPRLPTLSA QSSQPPGNAH FSVYNQLSQS QVRERGPSAS FPRERGLPQG CERKPPSPHL NAANEFLYSQ TFSLSRESSL QYHSGMGTVE NWTDG
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