Junctional adhesion molecule B (JAM2)

About Junctional adhesion molecule B

Junctional adhesion molecule B (JAM2) is a protein from Homo sapiens identified by UniProt accession P57087, 298 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.

Target properties

Protein name	Junctional adhesion molecule B
UniProt accession	P57087
Gene	JAM2
Organism	Homo sapiens
Length	298 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (84)

Diseases linked to this target (Open Targets).

basal ganglia calcification, idiopathic, 8, autosomal recessive · score 0.66
bilateral striopallidodentate calcinosis · score 0.37
hair color · score 0.23
genetic disorder · score 0.19
hair colour measurement · score 0.17
acute myeloid leukemia · score 0.12
rheumatoid arthritis · score 0.12
low grade glioma · score 0.10
neoplasm · score 0.05
PHF-tau measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57087-F1	alphafold	PREDICTED	83.02	—

Amino-acid sequence (298 residues)

MARRSRHRLL LLLLRYLVVA LGYHKAYGFS APKDQQVVTA VEYQEAILAC KTPKKTVSSR LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI IAAVVVVALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards