Krueppel-like factor 3 (KLF3)

About Krueppel-like factor 3

Krueppel-like factor 3 (KLF3) is a protein from Homo sapiens identified by UniProt accession P57682, 345 residues long. MolForge cross-references it against 0 known binders and 316 disease associations.

Target properties

Protein name	Krueppel-like factor 3
UniProt accession	P57682
Gene	KLF3
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (316)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.43
eosinophil count · score 0.41
leukocyte count · score 0.40
body mass index · score 0.39
lymphocyte percentage of leukocytes · score 0.38
reticulocyte count · score 0.37
neutrophil percentage of leukocytes · score 0.37
eosinophil percentage of leukocytes · score 0.36
mean platelet volume · score 0.34
neutrophil-to-lymphocyte ratio · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57682-F1	alphafold	PREDICTED	53.10	—

Amino-acid sequence (345 residues)

MLMFDPVPVK QEAMDPVSVS YPSNYMESMK PNKYGVIYST PLPEKFFQTP EGLSHGIQME PVDLTVNKRS SPPSAGNSPS SLKFPSSHRR ASPGLSMPSS SPPIKKYSPP SPGVQPFGVP LSMPPVMAAA LSRHGIRSPG ILPVIQPVVV QPVPFMYTSH LQQPLMVSLS EEMENSSSSM QVPVIESYEK PISQKKIKIE PGIEPQRTDY YPEEMSPPLM NSVSPPQALL QENHPSVIVQ PGKRPLPVES PDTQRKRRIH RCDYDGCNKV YTKSSHLKAH RRTHTGEKPY KCTWEGCTWK FARSDELTRH FRKHTGIKPF QCPDCDRSFS RSDHLALHRK RHMLV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards