Poly(rC)-binding protein 3 (PCBP3)

About Poly(rC)-binding protein 3

Poly(rC)-binding protein 3 (PCBP3) is a protein from Homo sapiens identified by UniProt accession P57721, 371 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Poly(rC)-binding protein 3
UniProt accession	P57721
Gene	PCBP3
Organism	Homo sapiens
Length	371 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.36
ankle injury · score 0.33
mathematical ability · score 0.24
BMI-adjusted waist circumference · score 0.22
forced expiratory volume · score 0.20
ganglion cell inner plexiform layer thickness measurement · score 0.20
refractive error measurement · score 0.19
Myopia · score 0.18
age at onset · score 0.16
PHF-tau measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57721-F1	alphafold	PREDICTED	67.25	—

Amino-acid sequence (371 residues)

MGEGDAFWAP SVLPHSTLST LSHHPQPQFG RRMESKVSEG GLNVTLTIRL LMHGKEVGSI IGKKGETVKK MREESGARIN ISEGNCPERI VTITGPTDAI FKAFAMIAYK FEEDIINSMS NSPATSKPPV TLRLVVPASQ CGSLIGKGGS KIKEIRESTG AQVQVAGDML PNSTERAVTI SGTPDAIIQC VKQICVVMLE SPPKGATIPY RPKPASTPVI FAGGQAYTIQ GQYAIPHPDQ LTKLHQLAMQ QTPFPPLGQT NPAFPGEKLP LHSSEEAQNL MGQSSGLDAS PPASTHELTI PNDLIGCIIG RQGTKINEIR QMSGAQIKIA NATEGSSERQ ITITGTPANI SLAQYLINAR LTSEVTGMGT L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards