Poly(rC)-binding protein 4 (PCBP4)

About Poly(rC)-binding protein 4

Poly(rC)-binding protein 4 (PCBP4) is a protein from Homo sapiens identified by UniProt accession P57723, 403 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	Poly(rC)-binding protein 4
UniProt accession	P57723
Gene	PCBP4
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
lung adenocarcinoma · score 0.28
endometrial cancer · score 0.28
breast adenocarcinoma · score 0.28
low grade glioma · score 0.28
gastric adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.27
cutaneous melanoma · score 0.25
macrophage inflammatory protein 1b measurement · score 0.12
multiple myeloma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57723-F1	alphafold	PREDICTED	66.49	—

Amino-acid sequence (403 residues)

MSGSDGGLEE EPELSITLTL RMLMHGKEVG SIIGKKGETV KRIREQSSAR ITISEGSCPE RITTITGSTA AVFHAVSMIA FKLDEDLCAA PANGGNVSRP PVTLRLVIPA SQCGSLIGKA GTKIKEIRET TGAQVQVAGD LLPNSTERAV TVSGVPDAII LCVRQICAVI LESPPKGATI PYHPSLSLGT VLLSANQGFS VQGQYGAVTP AEVTKLQQLS SHAVPFATPS VVPGLDPGTQ TSSQEFLVPN DLIGCVIGRQ GSKISEIRQM SGAHIKIGNQ AEGAGERHVT ITGSPVSIAL AQYLITACLE TAKSTSGGTP SSAPADLPAP FSPPLTALPT APPGLLGTPY AISLSNFIGL KPMPFLALPP ASPGPPPGLA AYTAKMAAAN GSKKAERQKF SPY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards