Caspase recruitment domain-containing protein 18…

About Caspase recruitment domain-containing protein 18

Caspase recruitment domain-containing protein 18 (CARD18) is a protein from Homo sapiens identified by UniProt accession P57730, 90 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Caspase recruitment domain-containing protein 18
UniProt accession	P57730
Gene	CARD18
Organism	Homo sapiens
Length	90 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
gut microbiome measurement · score 0.07
interleukin 18 measurement · score 0.06
Abnormality of refraction · score 0.03
depressive symptom measurement · score 0.03
nicotine dependence symptom count · score 0.03
refractive error · score 0.03
glioma · score 0.03
matrix metalloproteinase 12 measurement · score 0.02
visual perception measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57730-F1	alphafold	PREDICTED	90.67	—

Amino-acid sequence (90 residues)

MADQLLRKKR RIFIHSVGAG TINALLDCLL EDEVISQEDM NKVRDENDTV MDKARVLIDL VTGKGPKSCC KFIKHLCEED PQLASKMGLH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Caspase recruitment domain-containing protein 18 (CARD18)