T-cell leukemia translocation-altered gene protein…

About T-cell leukemia translocation-altered gene protein

T-cell leukemia translocation-altered gene protein (TCTA) is a protein from Homo sapiens identified by UniProt accession P57738, 103 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.

Target properties

Protein name	T-cell leukemia translocation-altered gene protein
UniProt accession	P57738
Gene	TCTA
Organism	Homo sapiens
Length	103 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (73)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.13
smoking cessation · score 0.13
age at menarche · score 0.12
mean corpuscular hemoglobin · score 0.12
unipolar depression · score 0.12
smoking initiation · score 0.10
mean corpuscular volume · score 0.10
wellbeing measurement · score 0.10
skin aging measurement · score 0.10
smoking behaviour measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57738-F1	alphafold	PREDICTED	65.75	—

Amino-acid sequence (103 residues)

MAESWSGQAL QALPATVLGA LGSEFLREWE AQDMRVTLFK LLLLWLVLSL LGIQLAWGFY GNTVTGLYHR PGLGGQNGST PDGSTHFPSW EMAANEPLKT HRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

T-cell leukemia translocation-altered gene protein (TCTA)