About Claudin-2
Claudin-2 (CLDN2) is a protein
from Homo sapiens identified by UniProt accession
P57739, 230 residues long.
MolForge cross-references it against 0 known binders and
349 disease associations.
Target properties
| Protein name | Claudin-2 |
|---|
| UniProt accession | P57739 |
|---|
| Gene | CLDN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 230 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (349)
Diseases linked to this target (Open Targets).
- azoospermia, obstructive, with nephrolithiasis · score 0.45
- male infertility · score 0.33
- endometrial cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.15
- acute pancreatitis · score 0.13
- necrotizing enterocolitis · score 0.09
- colitis · score 0.09
- breast cancer · score 0.09
- inflammatory bowel disease · score 0.08
- nephrotic syndrome · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57739-F1 | alphafold | PREDICTED | 79.42 | — |
Amino-acid sequence (230 residues)
MASLGLQLVG YILGLLGLLG TLVAMLLPSW KTSSYVGASI VTAVGFSKGL WMECATHSTG ITQCDIYSTL LGLPADIQAA QAMMVTSSAI SSLACIISVV GMRCTVFCQE SRAKDRVAVA GGVFFILGGL LGFIPVAWNL HGILRDFYSP LVPDSMKFEI GEALYLGIIS SLFSLIAGII LCFSCSSQRN RSNYYDAYQA QPLATRSSPR PGQPPKVKSE FNSYSLTGYV
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