Gasdermin-D (GSDMD)

About Gasdermin-D

Gasdermin-D (GSDMD) is a protein from Homo sapiens identified by UniProt accession P57764, 484 residues long. MolForge cross-references it against 0 known binders and 485 disease associations.

Target properties

Protein name	Gasdermin-D
UniProt accession	P57764
Gene	GSDMD
Organism	Homo sapiens
Length	484 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (485)

Diseases linked to this target (Open Targets).

C-reactive protein measurement · score 0.34
serum alanine aminotransferase measurement · score 0.28
Oral ulcer · score 0.24
aspartate aminotransferase measurement · score 0.24
ulcer disease · score 0.23
monocyte count · score 0.21
neutrophil count · score 0.18
leukocyte count · score 0.17
myeloid white cell count · score 0.16
neoplasm · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57764-F1	alphafold	PREDICTED	77.85	—

Amino-acid sequence (484 residues)

MGSAFERVVR RVVQELDHGG EFIPVTSLQS STGFQPYCLV VRKPSSSWFW KPRYKCVNLS IKDILEPDAA EPDVQRGRSF HFYDAMDGQI QGSVELAAPG QAKIAGGAAV SDSSSTSMNV YSLSVDPNTW QTLLHERHLR QPEHKVLQQL RSRGDNVYVV TEVLQTQKEV EVTRTHKREG SGRFSLPGAT CLQGEGQGHL SQKKTVTIPS GSTLAFRVAQ LVIDSDLDVL LFPDKKQRTF QPPATGHKRS TSEGAWPQLP SGLSMMRCLH NFLTDGVPAE GAFTEDFQGL RAEVETISKE LELLDRELCQ LLLEGLEGVL RDQLALRALE EALEQGQSLG PVEPLDGPAG AVLECLVLSS GMLVPELAIP VVYLLGALTM LSETQHKLLA EALESQTLLG PLELVGSLLE QSAPWQERST MSLPPGLLGN SWGEGAPAWV LLDECGLELG EDTPHVCWEP QAQGRMCALY ASLALLSGLS QEPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards